CIO Playbook: Agentic AI in the Enterprise
CXOTalk, Friday, May 15th, 2026
CIOs must shift from running systems to governing autonomous AI agents while maintaining security, risk management, and business value.
Episode 919 of CXOTalk explores how agentic AI is transforming the CIO's role and accountability in enterprises. As autonomous systems that plan, act, and call tools independently operate within workflows CIOs no longer fully control, boards continue to expect the same standards of security and risk management.
The episode provides a practical playbook addressing how CIOs should shift from system operations to governing autonomy, managing trust and control amid opaque vendor layers and shadow AI, designing human oversight for machine speed, and building governance models for continuous AI disruption. Featuring data scientist Anthony Scriffignano and CIO advisor Tim Crawford, the conversation covers concrete actions CIOs can take this quarter to lead enterprise AI transformation.